Isolated Russell Body Duodenitis with Concurrent Helicobacter Pylori Gastritis

Abstract

Russell body duodenitis (RBD) is a rare entity characterized by the accumulation of numerous cells with Russell bodies (RB) in the duodenal mucosa. The two previously reported cases were not associated with H. pylori infection. Herein, we report a case of RBD in a 59-year-old female patient with concurrent H. pylori gastritis. The polytypic nature of RB-containing plasma cells and the lack of immunoreactivity for cytokeratin indicate a benign nature. Our findings also support the notion that defective excretion of immunoglobulin, rather than the accumulation of H. pylori, is the underlying mechanism for RB formation.




J Med Cases. 2013;4(3):166-169
doi: https://doi.org/10.4021/jmc905w