Isolated Russell Body Duodenitis with Concurrent Helicobacter Pylori Gastritis

Derrick Chen, Prashanthi Thota, Xiuli Liu


Russell body duodenitis (RBD) is a rare entity characterized by the accumulation of numerous cells with Russell bodies (RB) in the duodenal mucosa. The two previously reported cases were not associated with <i>H. pylori</i> infection. Herein, we report a case of RBD in a 59-year-old female patient with concurrent <i>H. pylori</i> gastritis. The polytypic nature of RB-containing plasma cells and the lack of immunoreactivity for cytokeratin indicate a benign nature. Our findings also support the notion that defective excretion of immunoglobulin, rather than the accumulation of <i>H. pylori</i>, is the underlying mechanism for RB formation.

J Med Cases. 2013;4(3):166-169


Plasma cell; Russell body; Helicobacter pylori; Gastritis; Duodenitis

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