Primary Biliary Cholangitis Overlap With Autoimmune Hepatitis? A Case Report

Vitor Costa, Marta Moreira, Raquel Costa, Joana Fontes


Primary biliary cholangitis (PBC) is a chronic, autoimmune cholestatic disease, characterized by inflammation of the small and medium-sized bile ducts, which can lead to cirrhosis. Two to nineteen percent of patients with PBC have been reported to have features that overlap with autoimmune hepatitis (AIH). We report a case of a 39-year-old man with changes in liver biochemistry, with 6 years of asymptomatic evolution, whose diagnostic investigation determined the diagnosis of PBC, however with some features of AIH.

J Med Cases. 2021;12(4):131-133


Primary biliary cholangitis; Ursodeoxycholic acid; Anti-mitochondrial antibodies; Cirrhosis; Autoimmune hepatitis; Overlap syndrome

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