A Collision Tumor With Features of Breast Cancer and Plasma Cell Myeloma as Primary Tumors

Leila Moosavi, Sassan Farjami, Lisa Shane, Alireza Hosseini, Chester Choi

Abstract


Collision tumors, consisting of two different histological types of cancer, are rare but may have important implications, both for the patient and possibly in terms of cancer risks and predisposition. This patient has had prior invasive ductal breast cancer treated with surgery and chemotherapy 5 years earlier, but she developed a pathological hip fracture and anemia. The workup uncovered a plasma cell dyscrasia and the bone biopsy from the hip showed the collision tumor with an interface between breast cancer and plasma cell cancer. Such combination tumors may be diagnostic and therapeutic challenges, but they also raise significant questions regarding pathogenesis. Local factors such as neuro-immune crosstalk or cytokine perturbations may be at play. Alternatively, or in addition, oncogenic growth factors or the effects of prior chemotherapy may be significant.




J Med Cases. 2018;9(9):309-312
doi: https://doi.org/10.14740/jmc3117w

Keywords


Collision tumor; Histopathology; Monoclonal gammopathy; Plasma cell dyscrasia; Lytic/blastic bone lesions; Genetic predisposition

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.