A Collision Tumor With Features of Breast Cancer and Plasma Cell Myeloma as Primary Tumors

Leila Moosavi, Sassan Farjami, Lisa Shane, Alireza Hosseini, Chester Choi

Abstract


Collision tumors, consisting of two different histological types of cancer, are rare but may have important implications, both for the patient and possibly in terms of cancer risks and predisposition. This patient has had prior invasive ductal breast cancer treated with surgery and chemotherapy 5 years earlier, but she developed a pathological hip fracture and anemia. The workup uncovered a plasma cell dyscrasia and the bone biopsy from the hip showed the collision tumor with an interface between breast cancer and plasma cell cancer. Such combination tumors may be diagnostic and therapeutic challenges, but they also raise significant questions regarding pathogenesis. Local factors such as neuro-immune crosstalk or cytokine perturbations may be at play. Alternatively, or in addition, oncogenic growth factors or the effects of prior chemotherapy may be significant.




J Med Cases. 2018;9(9):309-312
doi: https://doi.org/10.14740/jmc3117w

Keywords


Collision tumor; Histopathology; Monoclonal gammopathy; Plasma cell dyscrasia; Lytic/blastic bone lesions; Genetic predisposition

Full Text: HTML PDF
 
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


 

     

Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board

Archives

Copyright

Company Profile

Editorial Office

Misconduct and Retraction

Permissions

Company Registration

Contact Us

Abstracting and Indexing

ICMJE

Ownership

Instructions to Authors

Access

Declaration of Helsinki

Contact Publisher

Submission Checklist

Reprints

Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy

Disclaimer

Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians

Careers

Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal

       
       

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

DECLARATION: THIS JOURNAL SITE OUTLOOK IS DESIGNED BY THE PUBLISHER AND COPYRIGHT PROTECTED. DO NOT COPY!