Oligomeganephronia in an Adult Presenting With Features of Chronic Kidney Disease

Yoichi Iwafuchi, Takashi Morita, Tetsuo Morioka, Takeshi Kamura, Yuko Oyama, Ichiei Narita


We report the case of a 29-year-old man with oligomeganephronia (OMN) who presented with symptoms of chronic kidney disease (CKD). Radiological and ultrasound images showed bilateral mildly small and uneven kidneys. Right renal biopsy was performed. Under light microscopy, the number of glomeruli in histological samples was decreased and the remaining glomeruli were markedly enlarged without mesangial proliferation. The obsolescent glomeruli had findings compatible with segmental sclerosis. Tubules were dilated and enlarged, and there was a presumptive primitive duct enclosed by a smooth muscle collar. Dysplastic changes in the biopsy specimen suggested that the cause of the patient’s small kidneys was a congenital anomaly rather than acquired kidney disease. OMN is one of the probable causes of CKD in adults. Angiotensin type II receptor blockers may be an effective treatment for focal segmental glomerulosclerosis due to OMN.

J Med Cases. 2015;6(8):362-366
doi: https://doi.org/10.14740/jmc2212w


Oligomeganephronia; Adult case; Chronic kidney disease; Focal segmental glomerulosclerosis; Renal hypodysplasia; Primitive duct; Angiotensin type II receptor blocker

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