J Med Cases
Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
Journal website http://www.journalmc.org

Case Report

Volume 5, Number 6, June 2014, pages 341-343


Chondrolipoma Arising in the Floor of the Mouth and Review of the Literature: A Case Report

Nagamani Narayanaa, c, Brent Henriksenb, John Caseya

aDepartment of Oral Biology, UNMC, College of Dentistry, 40th and Holdrege Street, Lincoln, NE 68583, USA
b1700S Southeastern Ave, Sioux Falls, SD 57103, USA
cCorresponding author: Nagamani Narayana, Department of Oral Biology, UNMC, College of Dentistry, 40th and Holdrege Street, Lincoln, NE 68583, USA

Manuscript accepted for publication February 18, 2014
Short title: Chondrolipoma in Floor of Mouth
doi: https://doi.org/10.14740/jmc1714w

Abstract▴Top 

Only 14 cases of chondrolipoma, a benign mesenchymal tumor containing mature cartilage and adipose tissue, have been reported from the oral cavity with tongue as the most common location. This case report describes a 56-year-old male with an asymptomatic mass in the floor of the mouth, which had doubled in size during the previous 6 months. This report is the first reported case of chondrolipoma arising in the floor of the mouth.

Keywords: Chondrolipoma; Floor of the mouth; Benign mesenchymal tumor

Introduction▴Top 

Lipoma, a benign mesenchymal tumor, occurs commonly on the trunk and extremities and infrequently in the oral cavity, presenting as soft, nodular masses in the buccal mucosa, buccal vestibule, tongue and floor of the mouth in both sexes with a median age of 40 years [1].

Rarely, lipomas containing cartilage have been reported in the tongue and lip [2]. These include chondrolipoma and chondroid lipoma. Chondrolipomas are defined as benign tumors containing mature cartilage and adipose tissue while chondroid lipoma contains immature cartilage. We report a chondrolipoma occurring in the anterior floor of the mouth, a site not previously described.

Case Report▴Top 

A 56-year-old Caucasian male presented with an asymptomatic mass in the floor of the mouth, which had doubled in size during the previous 6 months. Past medical history was positive for hypothyroidism treated with synthroid. He was a half pack-a-day smoker.

On oral examination, a rubbery mass 2.0 × 1.5 cm was noted in the anterior floor of the mouth (Fig. 1). Bilateral mandibular tori were also present. The clinical differential diagnosis included dermoid cyst and soft tissue tumors. An excisional biopsy was performed without complication. The area healed uneventfully (Fig. 2).

Figure 1.
Click for large image
Figure 1. Intraoral photograph showing a well-defined mass (1) in the anterior floor of the mouth.

Figure 2.
Click for large image
Figure 2. Intraoral photograph demonstrating healing area post excision (1).

The tan, soft tissue nodule was 1.5 × 1.3 × 1.0 cm with a glistening, white sectioned surface. Histologically, a well-circumscribed benign tumor composed of lobules of mature adipose tissue and mature hyaline cartilage separated by fibrous connective tissue in a fibromyxoid stroma was observed (Fig. 3, 4). The histological features were characteristic of chondrolipoma.

Figure 3.
Click for large image
Figure 3. Histology showing lobules of adipose tissue (1) and mature cartilage (2) in a fibrous connective tissue stroma (hematoxilin-eosin stain × 2).

Figure 4.
Click for large image
Figure 4. Histology showing lobules of adipose tissue (1) and mature cartilage (2) (hematoxilin-eosin stain × 10).
Discussion▴Top 

Chondrolipoma is a rare, benign tumor occurring at any age. A literature review of reported chondrolipomas revealed 10 cases in the tongue, three in the lip and one in the masseter [2-14] (Table 1). The present lesion is the first arising in the floor of the mouth. Nine cases including the present case occurred in males with an average age of 51 years. All lesions were excised and without recurrence. One case of chondrolipoma of the tongue in a two year old female is reported in the Spanish literature [8].

Table 1.
Click to view
Table 1. Review of Clinical Features of the Reported Cases of Oral Chondrolipomas
 

The differential diagnosis of floor of the mouth nodules/masses is dependent upon the location and consistency of the lesion. Ranula occurs commonly in the floor of the mouth, less commonly salivary gland tumors, dermoid cysts and mesenchymal tumors. The benign mesenchymal tumors include lipoma, neurofibroma and hemangioma. Dermoid cysts are uncommon true cysts, occurring in the midline of the floor of the mouth.

Conclusion

An unusual case of chondrolipoma clinically presenting as a red, rubbery mass in the floor of the mouth is reported. The demographics of all cases reported as chondrolipoma from the English literature are presented. The differential diagnosis of nodules/masses in the floor of the mouth is discussed.

Acknowledgments

Authors would like to thank Dr. Paul Freedman DDS, Oral Pathology Laboratory, INC NY for reviewing the case.


References▴Top 
  1. Naville B, Damm D, Allen C, Bouquot JOral and Maxillofacial Pathology. 3rd ed. 2009;
  2. Pitman KT, Bell D. Chondrolipoma of head and neck: case report and review of literature. Head Neck. 2013;35(1):E18-20.
    doi pubmed
  3. Berg T, Gorsky M. Chondrolipoma of the tongue: a case report of a rare diagnosis. Int J Dermatol. 2010;49(4):441-442.
    doi pubmed
  4. Bezerra MF, Costa FW, Pereira KM, Cavalcante RB, Pouchain EC. Chondrolipoma of the posterior tongue. J Craniofac Surg. 2010;21(6):1982-1984.
    doi pubmed
  5. Goel G, Khadilkar UN, Kumar S. Chondrolipoma of tongue. Kathmandu Univ Med J (KUMJ). 2008;6(24):505-507.
  6. Hietanen J, Makinen J. Chondrolipoma of the tongue. A case report. Int J Oral Maxillofac Surg. 1997;26(2):127-128.
    doi
  7. Maes A, Eulderink F. Chondrolipoma of the tongue. Histopathology. 1989;14(6):660-662.
    doi
  8. Nonaka CF, Miguel MC, de Souza LB, Pinto LP. Chondrolipoma of the tongue: a case report. J Oral Sci. 2009;51(2):313-316.
    doi pubmed
  9. Shabbir F, Greenwood M. Chondrolipoma presenting as a lump on the lateral tongue. Dent Update. 2011;38(3):188-190.
    pubmed
  10. Allard RH, Blok P, van der Kwast WA, van der Waal I. Oral lipomas with osseous and chondrous metaplasia; report of two cases. J Oral Pathol. 1982;11(1):18-25.
    doi pubmed
  11. McAndrew PG, Greenspan JS. Lipoma of lip with cartilage formation. Br Dent J. 1976;140(7):239-240.
    doi
  12. Fujimura N, Enomoto S. Lipoma of the tongue with cartilaginous change: a case report and review of the literature. J Oral Maxillofac Surg. 1992;50(9):1015-1017.
    doi
  13. Szudrowicz Z, Jakobi-Roz H. Chondrolipoma of the lip. A case report. Pol J Pathol. 1995;46(1):55-56.
    pubmed
  14. Batchvarova Z, Kadlub N, Coulomb-L'Hermine A, Picard A, Galliani E. Giant chondrolipoma of the tongue in a 14-year-old child with mandibular hypertrophy. Isolated lesion or regional overgrowth syndrome. Int J Oral Maxillofac Surg. 2012;41(2):261-264.
    doi pubmed


This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Journal of Medical Cases is published by Elmer Press Inc.

 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.