J Med Cases
Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 4, Number 12, December 2013, pages 825-827


Rare Cavitary MAC Lung Disease Causing a Serious Broncho-Pleural Air Leak in an Immune Competent Patient

Abdelkarim Waness

Department of Medicine, Mafraq Hospital, PO Box 2951, Abu Dhabi, UAE

Manuscript accepted for publication November 8, 2013
Short title: Cavitary MAC Lung Disease Causing Hydropneumothorax
doi: https://doi.org/10.4021/jmc1578w

Abstract▴Top 

Mycobacterium avium-intracellulare complex (MAC) is a non-tuberculous mycobacterium that can cause a variety of pathologies in both immune-competent and immune-deficient individuals. In this paper, I present a rare and unique case of severe MAC cavitary pulmonary disease complicated by a serious broncho-pleural air leak and persistent hydropneumothorax in a patient with normal immunity. His successful recovery took a lengthy antibiotic course and a segmental lung resection with pleural decortication. A brief discussion about MAC lung disease follows this presentation.

Keywords: Mycobacterium avium-intracellulare complex; Cavitary lung disease; Broncho-pleural fistula; Hydropneumothorax; Segmentectomy; Pleural decortication

Introduction▴Top 

Non-tuberculous mycobacteria, also known as atypical mycobacteria, are occasional human pathogens. These include: Mycobacterium avium-intracellulare complex (MAC), M. marinum, M. kansasii, and M. ulcerans. They usually infect individuals with decreased or blunted immunity but can be encountered in immunocompetent people. The spectrum of their pathologies includes lung infection, soft tissue disease, lymphatic involvement, and joint infection among others. In this paper, I am presenting a complicated case of MAC pulmonary disease in a person not known to have any immunodeficiency.

Case Report▴Top 

A 36-year-old diabetic man, on insulin replacement, was admitted with a 3-day history of left-sided chest pain and minimally productive cough. Clinically, the patient was mildly distressed. He had a temperature of 36.5 °C, respiration of 38/min, pulse of 119/min, BP of 128/79 mmHg, and SPO2 of 97% on room air. Auscultation showed left-sided reduced air entry and tachycardia. No palpable lymph nodes were found. The rest of the physical examination was unremarkable. Laboratory findings include: sodium 119 mmol/L (135 - 145 mmol/L), potassium 4.5 mmol/L (3.4 - 5.1 mmol/L), chloride 80 mmol/L (98 - 107 mmol/L), WBC 16.6 x 109/L (range 4.5 - 10 x 109/L), hemoglobin 16 g/L (117 - 155 g/L), and platelets 631 x 109/L (140 - 400 x 109/L). HIV serology was negative. Initial chest X-ray (CXR) discovered a large left hydropneumothorax, a completely collapsed left lung containing a large cavity, and severe right mediastinal shift (Fig. 1). A chest tomography (CT chest) confirmed these findings and demonstrated other smaller cavitary lesions in both lungs (Fig. 2).

Figure 1.
Click for large image
Figure 1. CXR showing large left hydropneumothorax with marked air-fluid level (large arrow), a collapsed left lung containing a cavity with another smaller air-fluid level (small arrow), and severe right mediastinal shift.

Figure 2.
Click for large image
Figure 2. CT chest showing large left hydropneumothorax with air-fluid level and multiple bilateral pulmonary cavities (arrows).

A large-bore chest tube was placed removing more than 500 mL of turbid pleural fluid that was negative for acid fast bacilli stains. Polymerase chain reaction (PCR) testing came back positive for MAC. A second PCR test confirmed the same microorganism.

The patient continued having dyspnea and tachycardia. Repeat CXRs showed persistent hydropneumothorax though smaller in size despite replacing chest drains. Subsequently bronchoscopy with broncho-alveolar lavage (BAL) was done. It confirmed the presence of a broncho-pleural fistula causing an expiratory air leak into the left pleural space. Fluid culture from BAL grew MAC. The patient was started on azithromycin, rifampin, and ethambutol. After protracted medical management for 2 months, he underwent successful left lung segmental resection and pleural decortication. He was discharged to finish his antibiotic course in the outpatient setting.

Discussion▴Top 

MAC is a ubiquitous non-tuberculous mycobacterium acquired via inhalation or ingestion. It can affect both immunocompetent and immunocompromised individuals [1]. MAC can infect many body organs such as lungs, liver, and spleen. In the respiratory system, it can cause a variety of diseases including: pneumonia, bronchiectasis, lung abscess/cavity, empyema, and pneumothorax [2].

Clinicians must be aware of possible MAC lung disease and pulmonary tuberculosis co-existence. Some authors advocate repeating a positive MAC PCR before embarking on treatment [3]. Rarely, MAC can cause severe hydropneumothorax from a ruptured lung cavity or broncho-pleural fistula as in this case. A multidisciplinary approach is usually needed in the management of MAC lung disease. This pathogen remains reasonably sensitive to few antibiotics (macrolides, quinolones, and so on) and antituberculous drugs (rifampin, ethambutol, and so on). It is usually treated with a drug combination for a period of 12 months [4, 5]. In case of MAC lung disease with broncho-pleural or alveolar-pleural fistulas, endobronchial valves insertion can be attempted by experienced pulmonologists [6]. In advanced non-tuberculous mycobacterial pleuro-pulmonary disease, surgical interventions such as segmentectomy, lobectomy, pneumonectomy, or pleural decortication might be required with varying degree of morbidity and mortality [7, 8].

Conclusion

MAC can cause severe pleuro-pulmonary disease in both immune-competent and immune-suppressed individuals. The diagnosis is confirmed by a combination of positive PCR test (preferably two tests), and cultures. Intractable hydropneumothorax is a dreaded complication that requires a lengthy multi-disciplinary intervention. MAC remains sensitive to quite a few drugs even though duration of therapy is lengthy. Finally, clinicians must pay special attention to possible MAC and Mycobacterium tuberculosis co-existence since therapeutic choices might change.

Conflict of Interest

None.

Funding Source

Nil.


References▴Top 
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