J Med Cases
Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 2, Number 2, April 2011, pages 55-57


Brain Abscess in a Patient With Decompensated Cirrhosis

Jun Katoa, Masahiko Kodaa, b, Yuki Fujisea, Shiho Tokunagaa, Tomomitsu Matonoa, Takaaki Sugiharaa, Takakazu Nagaharaa, Yoshikazu Murawakia

aSecond Department of Internal Medicine, Tottori University, School of Medicine, Yonago 683-8504, Japan
bCorresponding author: Masahiko Koda, Second Department of Internal Medicine, Tottori University, School of Medicine, Nishi-cho 36-1, Yonago 683-8504, Japan

Manuscript accepted for publication January 13, 2011
Short title: Brain Abscess in Decompensated Cirrhosis
doi: https://doi.org/10.4021/jmc128w

Abstract▴Top 

Brain abscess is rare but life-threatening, especially in a patient with decompensated cirrhosis. A 56-year-old woman with hepatitis B-related decompensated cirrhosis was admitted for disturbance of consciousness and high fever. She had right hemiparesis and mild neck stiffness, but no flapping tremor. Brain CT showed a low-density area in the left lenticular nucleus, indicating a brain abscess. She was given meropenem and ampicillin intravenously. Although the brain abscess improved, she died of progressive hepatic failure. In such patients, brain abscesses need to be distinguished from hepatic encephalopathy and treated quickly. Nevertheless, brain abscess in decompensated cirrhosis is extremely serious.

Keywords: Brain abscess; Liver cirrhosis; Sepsis; Disturbance of consciousness

Introduction▴Top 

Brain abscess is a life-threatening disease with a poor prognosis that often develops as an opportunistic infection in patients with impaired host defense mechanism due to malignancy, diabetes mellitus, alcoholism, and liver cirrhosis [1, 2]. Brain abscess develops either by spread from a contiguous focus or by hematogenous spread from a distant focus, such as intra-abdominal infection, endocarditis, urinary tract infection, or pulmonary infection.

Liver cirrhosis is an immune-compromised state because of reticuloendothelial dysfunction and porto-systemic shunting [3]. Bacterial infections in cirrhosis are common, particularly in decompensated patients, and they account for significant mortality [4]. A case of brain abscess in a decompensated cirrhotic patient is reported.

Case Report▴Top 

A 56-year-old woman had hepatitis B virus-related cirrhosis (Child-Pugh class C) and was medicated with Lamivudine. She was admitted to the emergency department in our hospital for disturbance of consciousness and high fever in May 2009. She had a history of previous episodes of hepatic encephalopathy and a small hepatocellular carcinoma treated by ethanol injection 2 years ago. She had no history of head trauma, contiguous infection, or diabetes mellitus. On admission, her level of consciousness was Glasgow Coma Scale score 9 (E1V4M4). Right hemiparesis and mild neck stiffness were suspected, but there was no flapping tremor. Her blood pressure was 120/50 mmHg, pulse rate 127/minute, and body temperature 39.4 °C. The laboratory test results were: total white blood cell count 15,400/mm3 with 93% neutrophils, C-reactive protein 1.26 mg/dl, hemoglobin 8.4 g/dl, platelet count 60,000/mm3, prothrombin time 42.0%, serum glucose 64 mg/dl, albumin 2.0 g/dl, total bilirubin 5.9 mg/dl, AST 47 IU/L, ALT 23 IU/L, NH3 92 µg/dl, alpha-fetoprotein 1.4 ng/ml and des-γ-carboxy prothrombin 17 mAU/ml, hepatitis B surface-antigen positive, e-antigen negative and hepatitis B virus-DNA negative. Blood cultures were negative for bacteria.

Plain brain computed tomography (CT) revealed a low-density lesion in the left lenticular nucleus and caudate nucleus, compressing the left lateral ventricle (Fig. 1a). We suspected a brain abscess and administered antibiotic (meropenem 0.5 g every 8 hours, intravenously) empirically. Her clinical course is shown in Figure 2. Her consciousness improved promptly, but 3 days later, it again deteriorated, and signs of meningeal irritation appeared. Brain contrast-enhanced CT showed an enlarged, low-density lesion with slight ring enhancement (Fig. 1b) [5]. To make a definite diagnosis, lumbar puncture was performed after platelet transfusion. Cerebrospinal fluid (CSF) analysis showed pleocytosis (leukocyte count 5,450/µl) and low glucose (3 mg/dl), but the CSF culture was negative for bacteria. A brain abscess with bacterial meningitis was diagnosed, and parenteral antibiotic therapy was intensified (meropenem 2 g every 8 hours, ampicillin 2 g every 4 hours). On the 6th day, brain contrast-enhanced magnetic resonance imaging (MRI) showed slight high-intensity areas on Fluid Attenuated Inversion Recovery and T1-weighted images, and high-intensity areas in bilateral lateral ventricles on diffusion-weighted images (Fig. 1c). These findings indicated bloody fluid and a brain abscess that ruptured intothe ventricle. Thereafter, though her brain abscess improved, her hepatic failure progressed and the patient died on the 134th day.

Figure 1.
Click for large image
Figure 1. (a) Plain brain computed tomography reveals a low-density lesion (arrow) in the left lenticular nucleus and caudate nucleus, and the left lateral ventricle is compressed. (b) Brain contrast-enhanced CT shows enlarged low-density lesion (arrow) with slight ring enhancement. (c) Brain contrast-enhanced magnetic resonance imaging shows high-intensity areas (arrow) on diffusion-weighted images in bilateral lateral ventricles, indicating rupture of the abscess into the ventricles.

Figure 2.
Click for large image
Figure 2. Clinical course.
Discussion▴Top 

Cirrhotic patients are susceptible to several infectious diseases, such as septicemia, meningitis, pneumonia, urinary tract infection, and spontaneous bacterial peritonitis (SBP) [4]. Six (11%) of 53 cases of brain abscess had liver cirrhosis [1]. Patients with liver cirrhosis presented with nonspecific symptoms, and all of them died soon. This high mortality in cirrhotic patients is associated with several factors. First, it is difficult to differentiate brain abscess from hepatic encephalopathy. Only 34% of patients have the complete triad, which is headache, fever, and focal neurologic deficits [1]. In the advanced stage of liver cirrhosis, hepatic encephalopathy is common and usually presents with disorientation, confusion, drowsiness, and coma; our patient had a past history of hepatic encephalopathy. Furthermore, cirrhotic patients can often have episodes of fever, caused by endotoxemia or SBP. Fortunately, in the present case, a neurologist suspected cranial infection because of mild neck stiffness and hemiparesis. However, neck stiffness occurs in only 8% of patients with brain abscess [1]. It is not always easy in clinical settings to detect mild neurological findings in patients with impaired consciousness. We should bear in mind the possibility of cranial infection when encountering cirrhotic patients with disturbance of consciousness and fever.

Second, bacterial infections worsen hepatic failure, and the prognosis is affected adversely even after resolution of infection [6, 7]. With infection, a systemic inflammatory response syndrome may occur, resulting in sepsis, renal failure, encephalopathy, and death. Increased endotoxins, bile acids, nitric oxide, and cytokines, such as tumor necrosis factor-α and interleukin-6, lead to systemic, renal, and hepatic hemodynamic derangements. In the present case, hepatic failure progressed gradually after resolution of the brain abscess, resulting in death. It may be important to start treatment as quickly as possible to prevent systemic inflammatory responses. Third, most cirrhotic patients are not surgical candidates because of their bleeding tendency and low hepatic reserve. Only 33% of cirrhotic patients received surgical treatment, compared with 66% of non-cirrhotic patients [1].

Liver dysfunction leads to several abnormalities of defense mechanisms because of depressed humoral and cell-mediated immunity. Bacterial translocation from the intestine induces bacteremia, and impaired hepatic bacterial clearance results in failure to control bacteremia [3]. In fact, some cases of brain abscess have been reported after endoscopic procedures, which induce bacteremia [8-10]. Severe bacteremia may cause infections of several organs, including brain abscess [4]. Furthermore, Klebsiella pneumoniae, which can colonize the gastrointestinal tract, is a common pathogen of brain abscess in cirrhotic patients [1, 11, 12]. In the present case, the pathogen causing the brain abscess could not be identified by blood and CSF cultures due to prior antibiotic therapy. Pathogenic bacteria are not identified in 30% of brain abscesses [1].

In conclusion, cirrhotic patients with central nerve system (CNS) infection could be easily misdiagnosed or diagnosed late because hepatic encephalopathy is a common complication of liver cirrhosis. When dealing with cirrhotic patients with impaired consciousness and fever, brain CT or MRI must be considered to exclude the presence of CNS lesions.


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