Occurrence of Buffalo Hump and Laryngeal Cancer in a HIV-1 Infected Patient with Metabolic Disorders Receiving a Rescue HAART Regimen

Alessandra Fantauzzi, Massimo Fusconi, Caterina Tripodi, Cristina Bigelli, Carmen Barbato, Giancarlo Ceccarelli, Ivano Mezzaroma


Reported cases of laryngeal squamous cell carcinomas are rare in HIV-1 infected patients. We describe a 68 year-old heavy smoker HIV-1 positive male receiving a salvage combination antiretroviral therapy, who developed a differentiated laryngeal cancer staging T3N0Mx after a 21 year history of HIV-1 infection. The patient also presented a severe fat redistribution with buffalo hump accompanied by subcutaneous adipose tissue lipoatrophy at arms and legs, and a dis-metabolic syndrome. Head and neck movements were severely limited by this voluminous mass. The presence of immune-suppression at the diagnosis with a relatively low grade staging of the neoplasm determined the choice of a combined chemo-radiation therapy, taking also in account the high infective risk linked to the surgery approach compared to that of acute toxicity reactions. A two years disease free follow up reinforced the needs of an early and accurate screening for neoplasms in HIV-1 infected patients.

J Med Cases. 2012;3(3):185-189
doi: https://doi.org/10.4021/jmc569w


HIV-1; HAART; Buffalo hump; HARS; Laryngeal cancer; Radiation therapy

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.