Eight Years Follow-up After Rush Specific Oral Tolerance Induction to Cow’s Milk Proteins

Mariana Couto, Angela Gaspar, Cristina Santa-Marta, Mario Morais-Almeida

Abstract


     Cow’s milk allergy (CMA) has a great impact on children and families quality of life. Recent studies point to a tendency for longer duration and greater severity. Specific oral tolerance induction (SOTI) to cow’s milk (CM) has been regarded as a promising strategy to improve care of these patients, but prospective data concerning tolerance and safety after ending SOTI are still lacking. The longest follow-up reported had the duration of 4 years. We report a case of a young male, now aged 20 year-old, with persistent CMA, successfully submitted to a rush SOTI CM protocol, which kept CM tolerance after 8 years. During this time he maintained daily CM ingestion and strictly followed doctor’s instructions. With a faster and easier to perform protocol we achieved the same efficacy as those reported before. The key to success could be the regular exposition to allergen. Publishing these case reports reinforces the safety and efficacy of SOTI therapeutic strategy.




doi:10.4021/jmc400w

Keywords


Anaphylaxis; Cow’s milk allergy; Follow-up; Oral tolerance induction; Protocol; Up-dosing; Weekly schedule

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