Long-Term Progression-Free Survival in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer Patient Treated With Crizotinib

Emad Mohsen Barsoum, Mahmoud Mohammed Eldemery, Nada Osama Osman, May Gamal Ashour, Mohsen Samy Barsoum

Abstract


Lung cancer is the second most common cancer worldwide. Non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) gene rearrangements constitutes 3-5%. Crizotinib was approved for the first-line therapy of advanced ALK-positive NSCLC patients. We present a female patient with advanced ALK-positive NSCLC who was kept on crizotinib as first-line therapy and showed progression-free survival (PFS) of 48 months despite the data suggesting that the majority of patients on crizotinib show relapse within 1 year. Further studies should focus on the molecular and biological factors and the possible effect of the long-term use of this drug.




J Med Cases. 2021;12(9):366-368
doi: https://doi.org/10.14740/jmc3743

Keywords


Crizotinib; ALK; Tyrosine kinase inhibitors; Non-small cell lung cancer

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