Gastrointestinal Stromal Tumor: An Uncommon but Serious Cause of Gastrointestinal Bleeding

Firas Alawawdeh, Amna Al-Tkrit, Mohammad Aneeb, Andrew Mekaiel, Asit Mehta


Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI tract that can sometimes present as a gastrointestinal bleeding source. This report describes a patient presented with upper GI bleeding secondary to a gastric GIST, which was initially detected on endoscopy. The patient underwent surgical resection of the tumor and was started on adjuvant chemotherapy with imatinib. The patients postoperative course was complicated by an esophageal leak requiring re-exploratory laparotomy and esophageal stent placement. The stent was removed 5 weeks later and the patient remained stable for discharge after 60 days of inpatient care.

J Med Cases. 2021;12(2):74-78


Gastrointestinal stromal tumor; KIT; DOG1; Upper GI bleeding; Imatinib; Tyrosine kinase inhibitor; Immunohistochemistry; Endoscopy

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