Acute Plasma Cell Leukemia Presenting as Primary Hyperammonemic Encephalopathy

Dveet Patel, Andrew Mangano, David Moccia, Shawn Esperti, Kunjan Udani, Jordan Henderson, Nino Balanchivadze


Primary plasma cell leukemia (PPCL) is a rare form of multiple myeloma (MM) and is a rare aggressive disease with a median overall survival of 6 - 11 months. We present a case of acute hyperammonemic encephalopathy as the initial presentation of PPCL in a 78-year-old woman to highlight an atypical presentation of this disorder.

J Med Cases. 2020;11(10):320-323


Plasma cell leukemia; Hyperammonemic encephalopathy; Multiple myeloma

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