Isolated Neutropenia: An Unexplored Side Effect of Amiodarone

Hiren Patel, David Peace


Amiodarone has been widely used for the treatment of various arrhythmias. It is a potent P450 inhibitor leading to interaction with many commonly prescribed drugs. Also, due to its long half-life, lipophilicity, and broad tissue distribution, it can cause a wide range of toxicities. A 62-year-old male with the unknown past medical history presented to the emergency department following a grand mal seizure. The patient initially presented with atrial flutter, which was controlled with beta blockers but was switched to amiodarone after 2 weeks when he developed atrial fibrillation with the rapid ventricular response. Approximately 1 month into his hospital stay, the patient developed severe isolated neutropenia. After ruling out other etiologies, amiodarone was withdrawn. The patients absolute neutrophil count recovered 3 days after discontinuation of amiodarone.

J Med Cases. 2020;11(1):1-5


Amiodarone; Isolated neutropenia; Supratherapeutic level; Voriconazole; P450

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