Report of Seven Cases of Langerhans Cell Histiocytosis in a Single Hospital in Japan

Takuji Tanaka, Riyoko Niwa, Fumimasa Etori, Asuka Ohashi, Ryogo Aoki, Naomi Kawaguchi, Toshimasa Sakakima, Rina Miyamae, Masashi Matsuyama, Naoki Watanabe


Langerhans cell histiocytosis (LCH), which shows a variable clinical presentation, is a disease that involves the proliferation of histiocytes. LCH occurs at any age and can affect a single system or multiple systems. The successful and accurate diagnosis of cases involving multiple organs requires a multidisciplinary approach. Since LCH receives limited attention, failure to recognize this disease in the early pediatric age can result in progression into adulthood. This study presents the clinical manifestations, imaging findings, pathological and cytological features, treatment strategies and prognoses of seven cases of LCH that are managed in a single hospital over the last 12 years. The ages of the patients ranged from 1 to 58 years. The sites at which LCH developed included the skin, lung, bone, lymph nodes and brain: one patient (adult male) had single-system/single-site LCH, three patients (adult male, adult female and girl) had single-system/multi-site LCH and three patients (adult female and two girls) had multi-system/multi-site LCH. BRAFV600E mutation was suggested in an adult female with multi-system/multi-site LCH and an adult male with single-system/multi-site LCH. We also discuss the pathogenesis and review the relevant literature.

J Med Cases. 2019;10(7):209-217


Langerhans cell histiocytosis; Histopathology; Cytopathology; Immunohistochemistry; Immunocytochemistry; Bone; Lung; Skin; Lymph node; Brain

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.