Cesium-Induced Acquired QT Prolongation Causing Ventricular Tachycardia and Torsades De Pointes: Fatal Complication of Over-the-Counter Supplements

Mahida Hetavi, Dawn Calderon, Ashish Patel, Mohammad A. Hossain

Abstract


Prolongation of the QT interval can be from congenital or acquired cause. It can lead to polymorphic ventricular tachycardia known as torsades de pointes (TdP). Many drugs have been known to prolong QT belonging to various pharmacologic classes, but most of them share one common pharmacological effect by lengthening the cardiac repolarization mostly by blocking specific cardiac K+ channels which leads to development of membrane oscillations (early after depolarizations) due to Ca2+/Na+ re-entry. Propagation early after depolarization leads to development of TdP. Cesium is an inorganic compound which has been shown to cause TdP in animal experimental model, but only few cases of high-dose cesium-induced bradycardia leading to QT prolongation have been reported in humans. We present a rare case of a lady who was taking low dose of cesium 500 mg daily leading to bradycardia and prolonged QT thus reflecting the variability in dose-dependent effects of acquired long QT substrates.




J Med Cases. 2019;10(6):155-157
doi: https://doi.org/10.14740/jmc3309

Keywords


Torsades de pointes; Cesium; QT prolongation

Full Text: HTML PDF
 

Browse  Journals

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.