Altered PD-L1 Expression in Non-Small Cell Lung Cancer Patient After Induction Chemotherapy: A Case Report

Abstract

Targeting the immune checkpoint of programmed death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) with immunotherapy has improved the treatment of many tumors including non small cell lung cancer (NSCLC). Checking PD-L1 status must be done during the course of therapy. Changes of PD-L1 status with therapy have been described in several cancer subtypes with different treatment modalities including chemotherapy and immunotherapy. Here we present a case report of a locally advanced squamous lung carcinoma patient presenting a decrease of PD-L1 level after chemotherapy. This case will be added to the few reports describing such changes in PD-L1 expression after different treatment modalities. More data are needed to understand the underlying mechanisms and its treatment implications.




J Med Cases. 2019;10(2):62-65
doi: https://doi.org/10.14740/jmc3249