Nuclear Protein of the Testis Midline Carcinoma

Ilda Coelho, Ana Antunes, Catia Cabral, Gloria Abreu, Guilherme Gomes


Nuclear protein in testis (NUT) carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangement that involve the gene encoding the NUT. This carcinoma was recognized in the thymus in 2004 WHO classification as a carcinoma with t(15;19) translocation, and it is also referred to as NUT carcinoma. However, currently, there is still sparse information about this entity which is treated as a very aggressive carcinoma with a median survival of 7 months. We report a case of a 20-year-old man with an aggressive growing pulmonary mass in the upper left lobe associated with bone metastasis. The bronchial and bones metastases biopsies presented a basaloid squamous cell carcinoma, which precipitated the examination for translocation t(15:19) and immunocytochemical study, both presenting positive results, which allowed establishing the diagnosis of NUT carcinoma.

J Med Cases. 2018;9(3):86-89


Nuclear protein in testis; Aggressive carcinomas; t(15;19) translocation

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.