Lethal but Reversible Encephalopathy Secondary to Lithium Toxicity: A Case Report and Review of Literature

Parthy Shah, Dhaval Khalpada, Dinesh Sangroula, Samir Sarkar


Lithium has been the first line of drug for bipolar disorder since the 1970s and is also efficient in treating acute mania and major depression. Due to its narrow therapeutic window, the risk of toxicity remains a concern. Clinical manifestations include gastrointestinal, cardiac, renal symptoms, and, in chronic intoxication, development of neurological symptoms. Here we report a rare case of a severe, life-threatening lithium intoxication in a 43-year-old male who was unresponsive with a very high serum lithium level of 5.0 mEq/L. Additionally, we discuss clinical profile, diagnostic examination, and management.

J Med Cases. 2017;8(12):375-377
doi: https://doi.org/10.14740/jmc2932e


Lithium; Lithium toxicity; Encephalopathy; Hemodialysis

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