Hepatocellular Carcinoma Developed From Non-Cirrhotic Liver: A Case Report

Ryuji Imagawa, Nobuhiro Takeuchi, Kazumasa Emori, Yasuo Kamiyama, Kaori Mohri, Shuho Semba

Abstract


Non-alcoholic steatohepatitis (NASH) is recognized as a crucial factor in the development of hepatocellular carcinoma (HCC) from non-viral cirrhosis. It is generally known that cirrhosis, fibrosis of the liver, works as a carcinogenic promoter, and it is uncommon for non-cirrhotic liver to develop into HCC. Here we report a case of HCC that developed from non-cirrhotic NASH. A 76-year-old male presented to our hospital with abdominal distention. His medical history included impaired glucose tolerance and hypertension. He denied any use of alcohol. Ultrasonography revealed a lobular mass in S5 of the liver with a marginal low echo that measured 50 × 40 mm. Contrast-enhanced computed tomography confirmed HCC. Laboratory analysis revealed normal hepatic and biliary enzymes, as well as normal levels of tumor markers, including alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II. Virus markers were negative for HBs-Ag, HBV-DNA, HCV-Ab, and HCV-RNA. As a result, he was chosen as a candidate for surgical resection; subsegmental resection of S5 and S6 was performed. The resected specimens of the tumor revealed moderately differentiated HCC; rich macrovesicular lipid depositions were observed over the background liver, which was compatible with A2F1. Based on the histological findings, he was diagnosed with HCC developed from non-cirrhotic NASH. This case report is informative for clinicians by raising awareness of the potential risk of HCC in non-cirrhotic NASH.




J Med Cases. 2016;7(11):508-511
doi: https://doi.org/10.14740/jmc2681w

Keywords


Hepatocellular carcinoma; Non-alcoholic steatohepatitis

Full Text: HTML PDF
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.