A Significant Discrepancy Between Endocrinological and Clinical Phenotype and Immunological Phenotype in Autoimmune Polyglandular Syndrome Type 3

Hidetaka Hamasaki, Hidekatsu Yanai, Chika Hiraishi, Sumie Moriyama


Autoimmune polyglandular syndrome (APS) is made up of a group of autoimmune disorders of the endocrine glands. In APS type 3, autoimmune thyroiditis occurs with another organ-specific autoimmune disease. APS type 3 is also associated with systemic autoimmune diseases such as sarcoidosis, Sjogren's syndrome and rheumatoid arthritis. We describe a 53-year-old woman with APS type 3 who showed a significant discrepancy between endocrinological and clinical phenotype and immunological phenotype.

J Med Cases. 2012;3(1):1-3
doi: https://doi.org/10.4021/jmc262w


Autoimmune thyroiditis; Autoimmune polyglandular syndrome; Rheumatoid arthritis; Sj

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