Stiff-Person Syndrome: A Case Report

Prabhjot Kaur Manes, Saif Mohammad Aslam, Melvin Varghese, Lia Elipulikattu


This is a case report of stiff-person syndrome (SPS) with episodes of paroxysmal autonomic dysfunction. A 67-year-old female with hypothyroidism, anxiety and hypertension presented with shortness of breath and diaphoresis for 1 day. The patient had been bedbound for several years due to muscle rigidity. She had two episodes of paroxysmal autonomic dysfunction treated with Ativan which resolved. Her anti-glutamic acid decarboxylase (GAD) antibody became abnormally high at > 250. She was treated with IVIG 30 g daily for 5 days as an inpatient and was discharged on 3 monthly IVIG treatment 1 g/kg × 2 days. This case report describes SPS with paroxysmal autonomic dysfunction.

J Med Cases. 2016;7(10):426-428


Stiff-person syndrome; Paroxysmal autonomic dysfunction

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