Rare Case Report of Multicentric Glioblastoma Multiforme Initially Mimicking With Herpes Simplex Encephalitis on MRI and Its Progression on Serial Imaging

Singh Rambir, Gupta Bharat, Kardam Narendra, Gehlot Kushalbabu


We report a case of a 58-year-old man with multicentric glioblastoma initially presenting as acute encephalitic illness. He presented with seizures and cognitive impairment in the emergency department of our hospital. Initially clinical and brain MRI findings were in favor of herpes simplex virus (HSV) encephalitis. The patient had initially improved after medical treatment. After 3 months, the patient complained of recurrent seizures. A follow-up brain MRI revealed marked increase in size of lesions and surrounding perilesional edema in the bilateral frontal lobes, cingulate gyrus and left insular cortex on T2-weighted images and lesions showed enhancement on post-contrast T1-weighted images. Patient underwent right frontal craniotomy and resection of lesion in right frontal region. The treatment is surgery or palliative, and management is controversial. The prognosis, however, remains unfavorable. Therefore, in elderly patients presenting with multifocal lesions on MRI of brain or atypical encephalitic symptoms, the rare possibility of multicentric glioblastoma multiforme should be considered as differential diagnosis.

J Med Cases. 2016;7(2):70-76
doi: http://dx.doi.org/10.14740/jmc2401w


Multicentric glioblastoma; HSV; Multiple intracranial lesions

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.