Mucinous Cystic Neoplasm of the Pancreas With Extensive Squamous Metaplasia

Abul Ala Syed Rifat Mannan, June S. Peng, Gareth Morris-Stiff, R. Matthew Walsh, John Hart, Xiuli Liu


Mucinous cystic neoplasm (MCN) of the pancreas with extensive squamous metaplasia of the lining epithelium is an extremely rare entity. We report such a case in a 25-year-old woman who underwent distal pancreatectomy for a cystic lesion of the pancreatic tail associated with left upper quadrant pain and acute pancreatitis. Microscopic examination revealed a cystic lesion lined entirely by squamous epithelium with subepithelial ovarian-type stroma, which demonstrated immunoreactivity for CD10, estrogen receptor, and FOXL2. Examination of the entire mass did not reveal any obvious lymphoid tissue, mucinous epithelium or endometrial type glands. We present this case to highlight extensive squamous metaplasia as a rare phenomenon in an otherwise typical MCN of the pancreas.

J Med Cases. 2016;7(5):187-190


Mucinous cystic neoplasm; FOXL2; Ovarian-type stroma; Squamous metaplasia

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