Psoriasis and Glucose-6 Phosphate Dehydrogenase Deficiency: A Rare Association?

Irfan Tursun, Gokhan Tazegul, Abdulkadir Bozbay, Seray Karagoz Ozdemir, Ozan Salim, Erkan Coban


Glucose-6 phosphate dehydrogenase (G6PD) is a vital enzyme for erythrocytes to be protected against oxidative stress. Its deficiency is the most common erythrocyte enzyme defect. Deficiency can cause acute or chronic hemolysis episodes. Hemolysis can be augmented by infections or drug use. Psoriasis is a complex autoimmune disorder characterized by skin involvement with inflammatory plaques. An otherwise healthy 37 years old male patient presented to internal medicine outpatient clinic with fatigue, generalized pain and skin lesions. Patient states that his sypmtoms got worse and worse after he took those medications. His past medical history was unremarkable. His family history reveals that his brothers son was recently diagnosed with G6PD deficiency. Quantitavite G6PD enzyme assay did not reveal any enzyme activity. Results were consistent with chronic hemolysis and G6PD enzyme deficiency was diagnosed as the cause. Patients skin lesions were consulted with dermatology and he was diagnosed with psoriasis. Because he had G6PD deficiency, he was only prescribed topical treatment. The patient was relieved of all generalized body pain. Here we present a case who presented with erythematous and squamataous plaques and malaise/generalized pain, diagnosed with G6PD deficiency and psoriasis. We discuss the possible relationship between two conditions.

J Med Cases. 2015;6(11):493-497


Psoriasis; Glucose-6 phosphate dehydrogenase deficiency; Hemolysis

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.