Human Papilloma Virus Associated Oropharyngeal Cancer in Pregnancy: Diagnostic and Management Challenge

Robyn Frances Coombe, Sandeep Bhuta


Human papilloma virus (HPV) associated head and neck cancer is a relatively new entity causing significant disease burden to otherwise healthy, young individuals. We describe the first case to our knowledge of HPV positive oropharyngeal cancer arising in a young pregnant woman. We discuss the implications of pregnancy on limiting management and treatment options and the need for timely multidisciplinary input. The case demonstrates how HPV squamous cell carcinoma is affecting a younger demographic and if not considered, can present as a diagnostic challenge. p-16 positive neck lymphadenopathy should be included in the differential diagnosis of a neck mass in a young patient. The case also illustrates the need for approved management guidelines in such a challenging clinical scenario.

J Med Cases. 2015;6(4):179-182


Head and neck neoplasms; Carcinoma; Squamous cell; Human papilloma virus 16; Pregnancy

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