Prolonged Bradycardia Induced by Bevacizumab-Associated Infusion Reaction in Advanced Metastatic Colon Cancer

Yuichi Mori, Shin-ei Kudo, Kunihiko Wakamura, Shingo Matsudaira, Masashi Misawa, Yuusaku Sugihara, Hideyuki Miyachi, Atsushi Katagiri, Toshiyuki Baba


A 71-year-old man complaining of bilateral leg edema and general fatigue was admitted to the hospital and diagnosed as advanced sigmoid colon cancer with multiple liver and lung metastasis. The 5-FU/leucovorin/oxaliplatin (FOLFOX)/bevacizumab was started as a first-line therapy. In the second course of FOLFOX/bevacizumab, just after finishing infusion of bevacizumab, he felt severe thrill with chill and got fever (maximum of 38.1 C). Since the symptom was diagnosed as an infusion reaction induced by bevacizumab, treatment with steroid and histamine antagonist was performed. His symptom disappeared soon after the treatment; however, his heart rate came lower below 50/minute 5 hours after the infusion reaction (his heart rate was routinely around 60/minute). The 12-lead electrocardiogram showed sinus bradycardia. The bradycardia (30 - 49/minute) continues at least 60 hours and spontaneously recovered. Literature search of PubMed showed just two papers implying the relation between bevacizumab and bradycardia. This case suggested that bradycardia induced by bevacizumab-associated infusion reaction should be carefully followed up and might be observed with admission if necessary.

J Med Cases. 2015;6(5):194-197


Infusion reaction; Colon cancer; Bevacizumab; Bradycardia

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.