Epstein-Barr Virus-Related Lymphoproliferative Disorder Caused by the Use of Antithymocyte Globulin and Cyclosporine for Aplastic Anemia

Shoji Suzuki, Torahiko Jinta, Naoki Nishimura

Abstract


A 70-year-old woman with aplastic anemia treated by antithymocyte globulin (ATG), cyclosporine and prednisolone visited our hospital complaining of fever and general fatigue for a week. A chest computed tomography (CT) scan showed consolidation in both lungs, and histological analysis of the lung tissue showed Epstein-Barr virus-positive diffuse large B-cell lymphoma. We diagnosed immunodeficiency-associated lymphoproliferative disorder, and consolidation of the lung was reduced after the cessation of cyclosporine. We should consider the possibility of malignant lymphoma when CT scan showed multiple patchy consolidations with random pattern in both lungs as septic pulmonary emboli in patients with immunosuppressive treatment.




J Med Cases. 2014;5(5):279-282
doi: http://dx.doi.org/10.14740/jmc1769w

Keywords


Epstein-Barr virus; Lymphoproliferative disorder; Antithymocyte globulin; Cyclosporine; Septic pulmonary emboli

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