Sulfasalazine-Induced Pancytopenia Indicative of Bone Marrow Suppression: A Case Report

Abdulrahman S Alanazi

Abstract


Ulcerative colitis (UC) is a chronic disease characterized by the inflammation and ulceration of the colon mucosa. The present case report of pancytopenia associated with sulfasalazine treatment substantiates a few other published reports and further our knowledge of sulfasalazine tolerability. We report a case of sulfasalazine-induced pancytopenia indicative of bone marrow suppression in an 18 years old Saudi girl with UC. After two months of treatment with azathioprine, sulfasalazine and prednisolone, her hematological indicators declined to a greater extent. Initially, all medications except sulfasalazine were stopped but hematology did not improve so that sulfasalazine was also discontinued, but prednisolone was used for the next 30 days. Hematological indicators of the patient were improved and sulfasalazine was restarted at a dose of 500 mg t.i.d. However, within a month, hematological indicators declined drastically, which led to discontinuation of sulfasalazine re-treatment. The case of sulfasalazine-induced pancytopenia presented herein is suggestive of bone marrow suppression keeping in view the previous reports of UC patients regarding the development of sulfasalazine-induced bone marrow suppression and associated pancytopenia.




J Med Cases. 2014;5(5):289-291
doi: http://dx.doi.org/10.14740/jmc1767w

Keywords


Sulfasalazine; Ulcerative colitis; Pancytopenia; Bone marrow suppression

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.