Graft Failure Following Allogeneic Stem Cell Transplantation for Primary Myelofibrosis: A Case Report

Max Mendez, Willem Bujan, Gabriela Granados


Myelofibrosis is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by marrow fibrosis, splenomegaly with cytopenias, constitutional symptoms and poor quality of life. Rates of graft failure following allogeneic stem cell transplantation range from 0 to 5%, being more frequent in non-HLA identical donors. Here we present an infrequent complication, a graft failure in a patient following identical sibling donor stem cell transplantation for myelofibrosis with objective indicators of disease remission.

J Med Cases. 2014;5(2):76-79


Primary myelofibrosis; Myeloproliferative neoplasm; Stem cell transplantation; Graft failure; Graft versus host disease

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