A Rare Syndrome in the Differential Diagnosis for Angioedema

Zeynep Celebi Sozener, Selcan Ozguclu, Omur Aydin, Aylin Okcu Heper, Sadan Soyyigit, Ayse Betul Sin


Melkersson-Rosenthal syndrome (MRS) is a rare, non-caseating chronic granulamatous neurocutaneous disease. MRS is frequently seen at the second or third decades of life. Classic triad was comprised of the recurrent facial nerve paralysis, orofacial edema and fissured dorsal tongue (lingua plicata). It is seen in 8-25% of the cases. The most important differential diagnosis of MRS is angioedema. Here we present two cases with MRS from our clinic. The first one is an example for the classic triad and the histopathological appearance is consistent with granulomatous cheilitis. The second case has an nonspesific histopathologic examination and was diagnosed clinically.

J Med Cases. 2014;5(11):579-582
doi: http://dx.doi.org/10.14740/jmc1543w


Angioedema; Melkersson-Rosenthal syndrome; Lingua plicata; Granulamatous cheilitis; Allergy

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