Treatment of Candida Glabrata With Micafungin: A Case Report and Brief Review of the Literature

Achyut Guleri, Daniel Gatt, Rashmi Sharma, Stephen Pettit

Abstract


We report the case of a patient with multiple Candida bloodstream infections post emergency laparotomy, Hartmann’s procedure, abdominal closure and drainage. The patient also experienced recurrent central venous catheter Candida infections. The treatment of Candida tropicalis bloodstream infection with fluconazole and caspofungin was initially successful; however the patient consequently developed Candida glabrata bloodstream infection which did not respond to therapy with fluconazole or caspofungin. Although at the time of treatment of this patient, the C. glabrata strain was considered to be susceptible to caspofungin, the new clinical breakpoints recently published by the Clinical and Laboratory Standards Institute show that this strain was in fact resistant to caspofungin. The patient was successfully treated with micafungin and a line lock was used for the Hickman line. This case study is the first documented European case report of successful treatment of breakthrough C. glabrata blood stream infection with micafungin. 




doi: http://dx.doi.org/10.4021/jmc1237w


Keywords


Candida glabrata; Echinocandins; Treatment; Microbial sensitivity tests; Disease management

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.