Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 3, Number 4, August 2012, pages 226-228


Probable Bexarotene Hepatotoxicity Associated With Transient Serum Antimitochondrial Antibodies

Table

Table 1. CIOMS/RUCAM Scoring for Hepatotoxicity
 
Type of liver injuryHepatocellular (first exposure)Points
Time of onset of the eventFirst exposure-
Time from drug intake until reaction onset< 5 or > 90 days+ 1
Course of the reaction> 50% improvement 30 days+ 2
Risk factors
  AlcoholNo+ 0
  Age ≥ 55 yearsNo+ 0
Concomitant therapyTime to onset incompatible+ 0
Exclusion of nondrug-related causesRuled out+ 2
Previous information on hepatotoxicityReaction labeled in product's characteristics+ 2
Response to re-administrationNot available+ 0
Total scoreProbable+ 7