Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 3, Number 1, February 2012, pages 49-53

Isolated Colonic Metastasis From Primary Invasive Ductal Breast Carcinoma: Role of Tumor Marker in Early Diagnosis


Figure 1.
Figure 1. Colonoscopy Image. There are markedly edematous folds in most of the right colon with multiple small superficial erosions.
Figure 2.
Figure 2. Colonic Biopsy Specimen 1. Immunohistochemical stain (CK7) highlights the metastatic carcinoma cells in the stroma of colonic mucosa (IHC, x 40).
Figure 3.
Figure 3. Colonic Biopsy Specimen 2. Immunohistochemical stain (GCDFP15) shows a few tumor cells react to antibody of Gross Cystic Disease Fluid Protein 15, which is a breast tissue marker, consistent with metastatic tumor of breast primary (IHC, x 40).


Table 1. Review of Literature Breast Cancer Metastasis to Colon
ReferencesAgePatientsTime since primary (year)HistologyMorphologyTumor markersSigns and symptoms
Taal et al [3]56174.4Ductal/lobularStrictureNAVaried
Theraux et al [4]69128DuctalStrictureNAObstruction
Feng et al [5]4912DuctalColonic erosionNAAbdominal Pain
Alves De lima et al [6]7417LobularStrictureNormalAnemia
Koustsomanias et al [7]6514DuctalNANAAnemia
Uygun K et al [8]4314.9Ductal/lobularStrictureNormalChange in bowel habits
Rabau et al [9]5317LobularStrictureNAObstruction
Schwarz et al [10]7510.25Ductal/lobularMucosal UlcerNAAbdominal mass
Okido et al [11]4815Ductal/lobularStrictureCEA 52.2
CA 15-3 normal
Abdominal mass
Vaidya et al [12]5615DuctalPolypoid tumorNAChange in bowel habits
Yokota et al [13]57110DuctalStrictureNAAsymptomatic