Figure 1. Eyelid edema in early mononucleosis known as Hoagland’s sign. Orange arrows indicate palpebral skin edema with evident flattening of the orbitopalpebral sulcus.
| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website https://www.journalmc.org |
Case Report
Volume 14, Number 6, June 2023, pages 208-212
Eyelid Edema May Be as a Sign of Dacryoadenitis in the Course of Epstein-Barr Virus Infectious Mononucleosis
Figure
Tables
| Exams | Results |
|---|---|
| ALT: alanine aminotransferase; AST: aspartate aminotransferase; EBV: Epstein-Barr virus; ESR: erythrocyte sedimentation rate; FT4: thyroxine free; GGT: gamma glutamine transferase; GOT: glutamic oxaloacetic transaminase; GPT: glutamic pyruvic transaminase; PCR: polymerase chain reaction; TSH: thyrotropin; WBC: white blood cells. | |
| WBC | 8.79 × 109/L (n.v. 4 - 10) |
| Neutrophil granulocyte | 46.3% |
| Lymphocytes | 39.9% |
| Monocytes | 9% |
| ESR | 2 mm/h (n.v. 2 - 28) |
| PCR | < 0.050 mg/dL (n.v. < 1) |
| IgM anti-EBV | > 160 U/mL (n.v. < 20) |
| AST (GOT) | 21 U/L (n.v. < 34) |
| ALT (GPT) | 19 U/L (n.v. < 55) |
| GGT | 21 U/L (n.v. < 73) |
| Creatinine | 0.93 mg/dL (n.v. 0.7 - 1.2) |
| Azotemia | 35 mg/dL (n.v. 15 - 50) |
| TSH | 5,332 µIU/mL (n.v. 0.4 - 4) |
| FT4 | 11.58 pg/mL (n.v. 10 - 25) |
| Author | Year | Number of cases |
|---|---|---|
| Appelmans et al [17] | 1967 | 1 |
| Decker et al [18] | 1991 | 1 |
| Marchese-Ragona et al [19] | 2002 | 1 |
| Burger et al [20] | 2005 | 1 |
| Inokuchi et al [21] | 2014 | 1 |
| Louppides et al [22] | 2019 | 1 |
| Bonito et al [23] | 2020 | 1 |
| Kano et al [24] | 2020 | 1 |
| Cherif et al [25] | 2021 | 1 |
| Nakagawa et al [26] | 2021 | 1 |
| Otsuki et al [27] | 2022 | 1 |
| Otsuka et al [28] | 2022 | 1 |
| Bronz et al [29] | 2022 | 14 |
| Ricardo et al [30] | 2022 | 1 |