J Med Cases

Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc

Journal website https://www.journalmc.org

Case Report

Volume 11, Number 10, October 2020, pages 317-319

A Rare Case of Systemic Mastocytosis With Associated Clonal Hematological Non-Mast Cell Lineage Disease That Transformed to Acute Leukemia With IDH2 Mutation

Figures

Figure 1. (a) Hematoxylin and eosin staining from aspirate (arrows pointed to mast cells). (b) Hematoxylin and eosin staining from biopsy (arrows pointed to mast cells). (c) Immunostaining positive for CD117 (arrows pointed to brown colored cells). (d) Immunostaining positive for CD25 (arrows pointed to brown colored cells). (e) Immunostaining positive for CD34 myeloblasts (arrows pointed to brown colored cells).

Figure 2. Disease history of WBC, HGB, platelet and tryptase over time. WBC: white blood cell; HGB: hemoglobin.

Table

**Table 1.** Response of CBC and Serum Tryptase Over Time
Lab result	8/30/16	11/7/16	9/20/17	11/13/17	6/14/18	9/1/19	3/16/20
WBC: white blood cell; HGB: hemoglobin; CBC: complete blood count.
WBC (per µL) (4,800 - 11,000)	11,100	12,700	8,100	21,200	9,800	2,000	8,000
HGB (g/dL) (14.0 - 18.0)	12.2	11.2	13.7	14.7	10.7	6.9	7.7
Platelet (per µL) (130,000 - 400,000)	86,000	87,000	134,000	105,000	135,000	28,000	4,000
Tryptase (ng/mL) (2.2 - 13.2)	-	295	141	243	275	124	5.3