Figure 1. (a) Low magnification view showing inflammatory change in ulcerative colitis, including crypt distortion, acute and chronic inflammation, and ulceration. (b) High-grade glandular dysplasia characterized by nuclear hyperchromasia, loss of nuclear polarity and increased mitotic activity.
Figure 2. (a) Invasive nests of signet ring cell carcinoma arising from colonic mucosa. (b) Low magnification view showing signet ring cell carcinoma invading the muscularis propria of the colonic wall. (c) Lymphatic tumor invasion. (d) Mucicarmine stain highlighting cytoplasmic mucin of the metastatic signet ring cell carcinoma in a pericolic lymph node.