Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 9, Number 9, September 2018, pages 281-283

Unusual Laboratory Results Suggest Late Development of Zika Virus-Specific Neutralizing Antibodies


Table 1. List of Zika Laboratory Tests Performed on Patient A and Their Results. The First Specimen Was Drawn 8 days After Arrival From an Area of Zika Risk, and the Second Specimen Was Drawn 74 Days After Arrival in the USA
SpecimenLaboratoryTest performedResult
Laboratories A, B, and C all refer to Public Health laboratories. NAT: nucleic acid testing referring to reverse transcriptase polymerase chain reaction (RT-PCR); IgM: immunoglobulin M referring to enzyme-linked immunosorbent assay (ELISA) testing the presence of IgM antibodies; PRNT: plaque reduction neutralization test.
First specimenAZika NATNegative
First specimenAZika IgMPresumptive positive
First specimenBZika NATPositive
First specimenBZika IgMPresumptive positive
First specimenCZika PRNT< 1:10 (negative)
First specimenCDengue PRNT< 1:10 (negative)
Second specimenAZika NATNegative
Second specimenAZika IgMPresumptive positive
Second specimenBZika NATNegative
Second specimenBZika IgMPresumptive positive
Second specimenCZika PRNT≥ 1:20 (positive)
Second specimenCDengue PRNT< 1:10 (negative)