Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 8, Number 11, November 2017, pages 347-350

A Rare Skin Manifestation in a Patient With Human Immunodeficiency Virus: A Case Report and Review of the Literature


Figure 1.
Figure 1. Tense, clear fluid-filled vesicles and blisters over normal and erythematous skin of the right upper extremity.
Figure 2.
Figure 2. Tense, clear fluid-filled vesicles and blisters over normal and erythematous skin of the trunk along with dried areas of healing skin.
Figure 3.
Figure 3. Hematoxylin-eosin stain (× 10). Subepidermal bullae containing eosinophils and polymorphs. The dermis shows perivascular infiltrates containing neutrophils and eosinophils.
Figure 4.
Figure 4. Healing skin lesions that were fluid-filled vesicles and blisters over the trunk and upper extremity 1 week after treatment.


Table 1. Bullous Pemphigoid Cases in Association With HIV Infection
No.AuthorDiagnosisAge, years/sexClinical findingsCD4 countTreatmentOutcomeInterval between HIV diagnosis and bullous eruption
BP: bullous pemphigoid; HIV: human immunodeficiency virus; M: male; F: female; PCP: pneumocystis carinii pneumonia.
1Levy et al [9]BP58/MGeneralized pruritis, excoriated erythematous papules, scarsNARitodrineRelapses and remissions1 year
2Bull et al [8]BP58/MTense blisters limited to legsNAPrednisoloneRelapses and remission. Died of PCP2 years
3Dipankar et al [7]BP-like eruption30/MTense, clear fluid filled bullae, well-defined, oozy erosion116/µLPrednisoloneUnder remission with treatment, no long-term follow-up10 years
4Present caseBP65/FTense clear fluid filled blisters diffuse all over the body517/µLPrednisoloneRemission with 3-month follow-up28 years