Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 8, Number 2, February 2017, pages 52-57

Remove the Ovarian Tumor, Cure the Encephalitis: Anti-NMDAR Encephalitis With Ovarian Teratoma in a Tertiary Hospital in Singapore


Table 1. Comparison of Four Cases
Case 1Case 2Case 3Case 4Summary
Age (years)2231263127.5 (mean)
Prodromal symptomsYNNN1/4
EEG abnormalityYYYN3/4
MRI brain abnormalityNNNY1/4
Ovarian pathology seen on CTNNNot doneN3/3
Size of tumor seen on US (cm)
Time from symptom onset to surgery (days)37872820 (mean)
Anti-NMDAR titer pre-surgery, serum1:1001:321:32Not quantified
Anti-NMDAR titer pre-surgery, CSF1:101:1001:10Not quantified
Type of surgeryLaparotomy ovarian cystectomyLaparotomy ovarian cystectomyLaparoscopic ovarian cystectomyLaparotomy unilateral salpingo-oophorectomy
Size of tumor, intraoperative (cm)2145
Frozen section resultBenignBenignNot performedBenign
Final histologyMalignantMalignantBenignMalignant
Intravenous steroidYYYY4/4
Second line immunosuppressantsNYNY2/4
Adjuvant chemotherapyNNNY1/4
Response to treatmentFull recoveryPartial recoveryFull recoveryFull recovery3/4