| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
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Case Report
Volume 7, Number 10, October 2016, pages 441-444
Severe Hypocalcemia After the Administration of Zoledronic Acid for Osteoporotic Fracture
Table
| D0 | D1 | D2 | D3 | D4 | D14 | D24 | D45 | 3 month | 5 months | |
|---|---|---|---|---|---|---|---|---|---|---|
| D0 means the day when the patient presented with hypocalcemia and serum calcium was measured at the first time. Ca IV indicates intravenous calcium gluconate therapy, 10 mL at 10%. | ||||||||||
| Serum levels | ||||||||||
| Calcium (Ca) (mg/dL) | 3.9 | 3.3 | 4.2 | 5.5 | 7.5 | 9.8 | 8.8 | 8.9 | 8.8 | 9.1 |
| Albumin (g/dL) | - | 3.3 | 3.4 | 3.2 | 3.4 | 4.0 | 4.1 | 4.2 | 4.4 | 4.2 |
| Corrected Ca (mg/dL) | - | 3.9 | 4.7 | 6.1 | 8.0 | 9.8 | 8.7 | 8.7 | 8.5 | 8.9 |
| Ionized Ca (mmol/L) | - | 0.46 | - | 0.74 | - | - | - | - | - | - |
| Phosphorus (mg/dL) | 1.3 | 3.1 | 2.4 | - | 2.3 | 1.6 | 2.0 | 2.3 | 2.7 | 2.7 |
| Creatinine (mg/dL) | 1.81 | 1.72 | 1.78 | 1.76 | 1.81 | 2.42 | 2.44 | 2.08 | 2.73 | 2.49 |
| eGFR | 29.5 | 31.3 | 30.0 | 30.4 | 29.5 | 21.1 | 20.9 | 25.1 | 18.3 | 20.4 |
| PTH (pg/mL) | 434.4 | 400.9 | - | - | - | 40.1 | 83.3 | - | - | - |
| 25(OH)D (ng/mL) | - | 5.8 | - | - | - | 13.3 | 11.1 | - | - | - |
| 1,25(OH)2D (pg/mL) | 11.9 | 9.4 | - | - | - | 93.2 | - | - | - | - |
| Magnesium (mEq/L) | - | 1.0 | - | - | - | 1.5 | - | - | - | - |
| Replacement | ||||||||||
| Ca IV | + | + | + | + | - | - | - | - | - | - |
| KH2PO4 IV | + | - | - | - | - | - | - | - | - | - |
| Oral Ca (g/day) | 0.6 | 1.2 | 1.8 | 1.8 | 1.2 | 0.4 | - | - | - | - |
| Oral calcitriol (μg/day) | - | 0.5 | 0.5 | 0.75 | 0.75 | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 |