Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 7, Number 5, May 2016, pages 174-177

An Intramucosal Large Cell Neuroendocrine Carcinoma Arising Within a Tubulovillous Adenoma With High-Grade Dysplasia of the Rectosigmoid Colon Treated With Polypectomy


Figure 1.
Figure 1. Histologic features of intramucosal NEC arising from a TVA with HGD. (a) Villous component of the adenoma (H&E stain, × 40); (b) HGD in the adenoma (H&E stain, × 200); (c) NEC in the lamina propria (H&E stain, × 400); (d) NEC with relation to adenoma (H&E, × 200).
Figure 2.
Figure 2. Immunophenotype of this high-grade NEC. (a) Strong and diffuse immunoreactivity of synaptophysin (peroxidasestain, × 100); (b) Focal immunoreactivity of chromogranin with a perinuclear dot-like staining pattern (peroxidase stain, × 200); (c) High Ki-67 labeling index (peroxidase stain, × 100).