Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 5, Number 12, December 2014, pages 631-633

A Case of Crizotinib-Resistant Lung Adenocarcinoma Harboring a KRAS Mutation and an EML4-ALK Fusion Gene


Figure 1.
Figure 1. Chest radiography revealed a mass shadow in the right lower lung field (A). Histology of the primary tumor showed an invasive mucinous adenocarcinoma (hematoxylin and eosin stain, × 100 magnification, internal scale bar = 200 μm) (B).
Figure 2.
Figure 2. KRAS mutation of codon 12 was positive. Variant 1 of the EML4-ALK translocation was identified by RT-PCR and sequencing assays.
Figure 3.
Figure 3. Comparison of computed tomography scans of the thorax before crizotinib (A), and 42 days after crizotinib treatment (B) showed tumor enlargement.