Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 5, Number 7, July 2014, pages 413-416

Silicone Breast Implants as Predisposing Factor for Non-Hodgkin’s Lymphoma: An Additional Facet of Auto-Inflammatory Syndrome Induced by Adjuvant


Figure 1.
Figure 1. Abdominal CT scan with intravenous contrast injection. Para-aortic lymphadenopathy (black arrows) and left retroperitoneal and mesenteric root soft tissue infiltration (white arrows). Bladder wall thickening (curved arrow) and ascites seen at upper abdomen. (A) Axial slice at mid-abdomen. (B) Coronal image.


Table 1. Suggested Criteria for the Diagnosis of “ASIA”
ASIA: autoimmune (auto-inflammatory) syndrome induced by adjuvants; HLA: human leukocyte antigen; MS: multiple sclerosis; SSc: systemic sclerosis.
Major criteriaExposure to an external stimuli (infection, vaccine, silicone, adjuvant) prior to clinical manifestations.
The appearance of “typical” clinical manifestations:
Myalgia, myositis or muscle weakness
Arthralgia and/or arthritis
Chronic fatigue, un-refreshing sleep or sleep disturbances
Neurological manifestations (especially associated with demyelination)
Cognitive impairment, memory loss
Pyrexia, dry mouth
Removal of inciting agent induces improvement
Typical biopsy of involved organs
Minor criteriaThe appearance of autoantibodies or antibodies directed at the suspected adjuvant
Other clinical manifestations (i.e. irritable bowel syn.)
Specific HLA (i.e. HLA DRB1, HLA DQB1)
Evolvement of an autoimmune disease (i.e. MS, SSc).