Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 6, Number 1, January 2015, pages 40-42

Cold Urticaria: A Rare Manifestation of Lymphoma


Figure 1.
Figure 1. The appearance of skin after applying ice cube test.
Figure 2.
Figure 2. Skin biopsy taken from lesion showed evidence of leukocytoclastic vasculitis by light microscopy. There is a mild neutrophilic infiltrate in the wall of small vessel located in the superficial dermis. Also mild congestion and leukocytoclasis is also present. H&E, × 200.
Figure 3.
Figure 3. (A, B) The lymph node excision showed atypical lymphoid infiltration (H&E, × 40, × 400). (C, D) Immunohistochemically, the neoplastic cells were positive for CD20 and kappa light chain (× 25, × 40). (E) Paratrabecular nodular infiltration was seen in the bone marrow (H&E, × 25). (F, G, H) The lymphoid cells expressed CD20 and kappa light chain; lambda was negative (× 25, × 40, × 40).