Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 4, Number 8, August 2013, pages 519-522

Rosai-Dorfman Disease Confined to the Breast


Figure 1.
Figure 1. Photo microscopy of breast lesion, showing intense chronic inflammatory infiltrate composed of plasma cells, histiocytes and lymphocytes (Hematoxylin-eosin staining, with 100 ×).
Figure 2.
Figure 2. It is observed intact lymphocytes within the histiocyte, undigested, a phenomenon called Emperipolesis (Hematoxylin-eosin staining, with 400 ×).
Figure 3.
Figure 3. (a, b). Macroscopic surgical specimen; whitish-yellowish, with brownish areas in between, jagged edges and asymmetrical weighing 15.58 g.


Table 1. Reported Cases of Rosai-Dorfman Disease in the Breast
Author/yearNumber of cases
Perez/19932 cases
Hammond/19961 case
Soares/19991 case
Govender /19971 case
Green/19977 cases
Hummel/19991 case
Pham/20051 case
Ng SB/20001 case
Perera/20072 cases
Kuzmiak/20031 case
Picon/20101 case
Silotti/20121 case