| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website http://www.journalmc.org |
Case Report
Volume 4, Number 7, July 2013, pages 481-484
Dexmedetomidine and Pulmonary Hypertension: A Case Report and Review of the Literature
Table
| Author and references | Clinical situation | Dexmedetomidine dosing and outcome |
|---|---|---|
| PAH = pulmonary artery hypertension | ||
| Nathan AT et al [16] | 16-year-old with impending respiratory failure due to pneumonia. PAH due to chronic lung disease since infancy. | Dexmedetomidine used to provide anxiolysis during increased work of breathing.The dexmedetomidine infusion was started at 0.5 µg/kg/hour and continued for 48 hours with effective pain control and anxiolysis. |
| Munro HM et al [17] | 12-year-old with idiopathic PAH undergoing cardiac catheterization for reactivity to guided therapeutic options. | Ketamine 15 mg bolus times two followed by dexmedetomidine (loading dose of 1 µg/kg followed by an infusion of 1 µg/kg/hr). The dexmedetomidine infusion was continued at 0.5 µg/kg/hr for 2 hours postoperatively to provide sedation due to behavioral concerns. Hemodynamic stability maintained throughout. |
| Toyama H et al [18] | 30-year-old with severe PAH for caesarean section at 32 weeks under general anesthesia. | Dexmedetomidine (0.4 µg/kg/hour) was used to provide postoperative anxiolysis and prevent emergence agitation following general anesthesia and during tracheal extubation. |
| Shinohara H et al [19] | 21-year-old requiring monitored anesthesia care during regional anesthesia for inguinal hernia repair | Dexmedetomidine at 0.2-0.3 µg/kg/hour used to provide sedation and anxiolysis during Ilioinguinal-iliohypogastric block and subsequent surgical procedural. |