Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 4, Number 6, June 2013, pages 380-384

Fahr’s Syndrome due to Hypoparathyroidism Following Thyroidectomy


Figure 1.
Figure 1. Non-contrast computed tomography scan of the brain showing diffuse calcifications in cerebellum, basal ganglia, semioval centers, thalamus, frontal, temporal, and occipital white matter.


Table 1. Conditions Associated With Basal Ganglia Calcification on Neuroimaging
EndocrineHypoparathyroidsm, pseudohypoparathyroidism pseudopseudohypoparathyroidism, hypothyroidism and hyperparathyroidism.
Hypoxic and vascularAteriovenous malformation, calcified infarct, and ischemic encephalopathy.
Inflammatory/InfectiousCytomegalovirus infection, tuberculosis, measles, toxoplasmosis, neurobrucellosis, mumps, congenital rubella, neurocysticercosis, varicella, acquired immunodeficiency syndrome, coxsackie B infection, and systemic lupus erythematous.
ToxicCarbon monoxide intoxication, lead poisoning, hypervitaminosis D, methotrexate therapy, and radiotherapy.
GeneticFamilial idiopathic basal ganglia calcification (Fahr’s disease), idiopathic lenticulodentate calcification (Hastings-James syndrome), Cockayne’s syndrome, Griscelli disease, MELAS (mitochondrial, myopathy, encephalopathy, lactic acidosis, and stroke) syndrome, MERRF (myoclonic epilepsy with ragged red fibers) syndrome, Kearns-Sayre syndrome, Leigh’s disease, Sturge-Weber-Dimitri syndrome, Down’s syndrome, lipoid proteinosis (Urbach-Wieth disease), carbonic anhydrase II deficiency syndrome, biopterin deficit, leukodistrophic diseases, arthrogryposis, and tuberous sclerosis.
OtherSenility, malabsorption, motor neuron disease.