Figure 1. Timeline of the case report.
| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website http://www.journalmc.org |
Case Report
Volume 6, Number 10, October 2015, pages 468-471
A Neuropsychiatric Presentation of Seronegative Autoimmune Encephalitis: A Case Report
Figure
Table
| Test | Day | Results |
|---|---|---|
| MRI: magnetic resonance imaging; EEG: electroencephalography; US: ultrasound; CT TAP: CT thorax, abdomen, and pelvis; CTPA: CT pulmonary angiography; CSF: cerebrospinal fluid; WCC: white cell count; HSV: herpes simplex virus; RNA: ribonucleic acid; VZV: varicella zoster virus. | ||
| Imaging, EEG and CSF analysis | ||
| Brain CT | 1 | No abnormalities detected |
| Brain MRI | 2, 4 | No abnormalities detected |
| Pelvic US | 7 | No abnormalities detected |
| EEG | 1, 2 | Moderate to severe encephalopathy, no delta brush |
| CT TAP | 3 | No abnormalities detected |
| CTPA | 14 | No abnormalities detected |
| CSF microscopy | 1 | WCC = 78/mm3 (100% lymphocytes), glucose and total protein = normal range |
| CSF microscopy | 6 | WCC = 7/mm3 (no differentials), glucose and total protein = normal range |
| Infection markers | ||
| CSF viral screen (HSV1, HSV2, measles RNA, mumps RNA, VZV, enterovirus RNA) | 1, 6, 17, 22 | Negative |
| CSF culture and sensitivity | 1, 6, 17, 22 | Negative |
| Anti-extractable nuclear antibody | 4 | Negative |
| Syphilis total antibody | 4 | Negative |
| Anti-streptolysin (ASO) titer | 4 | Negative |
| Hepatitis C antibodies, hepatitis B surface antigens | 13 | Negative |
| Lyme disease serology | 15, 53 | Negative |
| Autoimmune, paraneoplastic and metabolic markers | ||
| Anti-Yo and anti-Hu | 9 | Negative |
| CEA19.9, CA125, CA15.3 | 9 | Negative |
| Prophyria screen | 20 | Negative |
| Ceruplasmin and copper | 4 | Normal range |
| CSF and serum NMDA-R, VGKC, AMPAR-a, AMPAR-b, GABA-b receptor antibodies | 4 | Negative |
| Anti-neutrophil cyto ab, anti-nuclear ab, anti-mitochondrial ab, anti-smooth mucle ab, anti-gastric parietal cell ab, anti-thyroid peroxidase ab | 4 | Negative |
| CSF immunoglobulin (IgG) | 17, 22 | Intrathecal IgG elevated, no oligoclonal bands detected |